Toxicologic pathology is a rewarding and challenging discipline that touches the daily lives of nearly everyone. We hope that this review promotes understanding of the important role the toxicologic pathologist plays in drug development and encourages exploration of an important career option. The biopharmaceutical industry provides diverse, challenging, and rewarding career opportunities in toxicologic pathology. Educational and specialized training requirements and the challenges of working in a global environment are discussed.
We describe the role of toxicologic pathologists in identifying candidate agents, elucidating bioactive pathways, and evaluating efficacy and toxicity in preclinical animal models. This review is part of an initiative by the Society of Toxicologic Pathology to educate scientists about toxicologic pathology and to attract junior scientists, veterinary students, and veterinarians into the field. As the members of multidisciplinary teams, toxicologic pathologists participate in all aspects of the drug development process. Toxicologic pathologists contribute significantly to the development of new biopharmaceuticals, yet there is often a lack of awareness of this specialized role.
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